When to Use Niacinamide Serum: Morning, Night, or Both? | Rysun Biotech

Friday, 12/12/2025

Discover the best time to apply Vitamin B3 for maximum results. Rysun Biotech’s R&D experts explain when to use niacinamide serum in your routine for oil control and barrier repair.

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Timing Your Glow: Exactly When to Use Niacinamide Serum for Peak Efficacy

Introduction
Niacinamide, also known as Vitamin B3, has earned its place as a "holy grail" ingredient in modern skincare. However, its versatility often leads to one common question: "When to use niacinamide serum for the best results?"

At Guangzhou Rysun Biotechnology, we believe that timing is a science. Founded in 2014 by Ivy Wong following high-level discussions with a Swiss anti-aging expert, Rysun was established to eliminate the "inconsistent quality" found in the market. With over 10 years of experience and 253 intellectual properties, our Research Institute has analyzed exactly how this ingredient interacts with the skin’s daily cycle.

Here is our professional guide on the "when," "where," and "how" of Niacinamide application, and our private label serum collection is here.

 

1. Day or Night: When is Best?

The short answer is: Both. Niacinamide is a non-sensitizing, stable antioxidant that does not increase sun sensitivity, making it a rare ingredient that provides unique benefits during both the AM and PM.

  • In the Morning (AM): Using Niacinamide during the day focuses on protection. It helps regulate sebum (oil) production throughout the day and strengthens the skin’s barrier against environmental pollutants.
  • In the Evening (PM): Using it at night focuses on repair. This is when your skin goes into "recovery mode." Niacinamide supports the production of ceramides, helping to heal the skin barrier while you sleep.

2. The Step-by-Step Routine Order

To maximize the 105 product patterns we’ve developed at Rysun, our R&D experts recommend following the "Thin-to-Thick" rule:

  • Cleanse: Start with a fresh face.

  • Tone: Balance the skin’s pH.

  • Niacinamide Serum: This is the precise time when to use niacinamide serum. Because it is usually water-based, it should be applied to clean, slightly damp skin before heavier oils or creams.

  • Moisturize: Seal in the serum with a cream.
  • SPF (Daytime): Always protect the skin after your routine.

3. When to Use for Specific Skin Concerns

Our team of 20 leading scientific researchers has identified specific "trigger moments" when Niacinamide becomes essential:

  • During a Breakout: Use it to soothe inflammation and prevent post-acne dark spots.
  • In Seasonal Transitions: When the weather changes and the skin barrier feels "tight" or compromised, Niacinamide is the practical solution for restoration.
  • When Layering with Retinol: Retinol can be irritating. Using Niacinamide before or with Retinol can actually buffer the skin and reduce redness.

 

The Rysun Quality Advantage

Why does the "when" matter so much to us at Rysun? Because a research-driven company knows that ingredient stability is everything.

  • 50 Inspection Procedures: We implement up to 50 strict checks per product to ensure that our Niacinamide remains active and stable from the moment you apply it in the morning until it finishes its work at night.
  • Global Insights: Partnering with over 700 brands across 50 countries, we’ve seen that Niacinamide is the ultimate "practical solution" for various climates—whether it's managing humidity-induced oil in the morning or dry-winter dehydration at night.

Conclusion

Knowing when to use niacinamide serum is the key to unlocking a clearer, more resilient complexion. Whether you choose to use it as a daytime shield or a nighttime repair treatment, its benefits are undeniable.

At Rysun Biotechnology, we combine Swiss-inspired standards with a decade of manufacturing expertise to ensure that every drop of serum we produce meets the highest global standards. If you are looking to launch a high-performance Niacinamide line, our professional team is ready to help you formulate the perfect solution.

 

FAQs

Q1: Can I use Niacinamide with Vitamin C?
A: Yes. Modern R&D—including Rysun’s proprietary research—shows that today’s stable forms of Vitamin C and Niacinamide can be used together in the same routine without issues.

Q2: Is there anyone who should NOT use it?
A: Niacinamide is safe for almost all skin types. However, if you have extremely sensitive skin, we recommend starting with a 5% concentration rather than 10%. Rysun offers various concentration patterns to suit different market needs.

Q3: How long does it take to see results?
A: While you may notice better oil control in days, our clinical insights suggest it takes 4 to 8 weeks of consistent use (AM and PM) to see a significant reduction in pore size and hyperpigmentation.

Q4: Does Rysun offer customized Niacinamide formulas?
A: Absolutely. With 253 intellectual properties, we can customize textures, concentrations, and synergistic ingredient blends to help your brand stand out.

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