How to Use Niacinamide Serum: A 5-Step Expert Guide | Rysun Biotech

Friday, 12/12/2025

Confused about how to use niacinamide serum? From layering to dosage, Rysun Biotech’s R&D experts explain the science of applying Vitamin B3 for maximum pore-refining results.

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Mastering the Glow: How to Use Niacinamide Serum Correctly According to Science

Introduction
Niacinamide (Vitamin B3) has become the "Swiss Army Knife" of the beauty world. It regulates oil, minimizes pores, soothes redness, and brightens tone. But even the best ingredient fails if applied incorrectly. As a result, "how to use niacinamide serum" is one of the most common questions in skincare today.

At Guangzhou Rysun Biotechnology, we don't just manufacture products; we engineer routines. Established in 2014 by Ivy Wong to solve the industry's issue of inconsistent quality, and inspired by a Swiss anti-aging expert, we approach application methods with the same rigor as we do formulation.

Backed by our Research Institute and 20 leading scientists, here is the definitive guide on incorporating Niacinamide into your regimen for optimal results.

Here is our private label Niacinamide serum, pls click here for more information.

 

Step 1: Start with a Clean Canvas

Niacinamide is water-soluble, meaning it absorbs best into clean, oil-free skin.

  • The Method: Wash your face with a gentle cleanser.
  • The Rysun Insight: Ensure your cleanser doesn't leave a heavy residue. Our R&D team formulates Niacinamide serums to be lightweight, so they need direct contact with the pores to regulate sebum effectively.

Step 2: Apply Toner (Optional but Recommended)

If you use a toner, apply it before the serum.

  • The Method: Swipe your toner and let it settle for 30 seconds.
  • The Rysun Insight: Keeping the skin slightly damp can help water-based Niacinamide serums absorb better.

Step 3: The Application (The "How-To")

This is where most people go wrong—using too much product.

  • The Method: Dispense 2-3 drops of serum into your palms. Gently press (pat) it into your face and neck. Do not rub aggressively.
  • The Rysun Difference: High-quality serums shouldn't be sticky. Leveraging our 105 product patterns, Rysun manufactures Niacinamide serums with "cosmetic elegance"—meaning they absorb instantly without the soapy, white-cast effect found in cheaper formulations.

Step 4: Layering (What Goes First?)

"How to use niacinamide serum" often involves understanding its place in a multi-step routine. The rule of thumb is Thinnest to Thickest.

  • Before: Watery essences.
  • After: Heavy creams or oils.
  • With Other Actives: You can use Niacinamide with Hyaluronic Acid, Retinol, and Peptides.
  • The Vitamin C Myth: Old science said you couldn't mix Niacinamide and Vitamin C. Modern science—and Rysun’s own 253 intellectual properties—confirms that highly stable forms of these ingredients can be layered safely for a brightening power-boost.

Step 5: Seal with Moisturizer

Niacinamide helps strengthen the skin barrier, but it is not a standalone moisturizer.

  • The Method: Always follow with a lotion or cream to lock the active ingredients in.
  • The Rysun Insight: Our "Practical Solutions" philosophy suggests using a moisturizer containing ceramides. This pairs perfectly with Niacinamide to repair the barrier from both the inside and outside.

 

Expert Tips: The Science of Concentration

When learning how to use niacinamide serum, percent matters.

  • The Sweet Spot: Studies show that 2% to 5% is effective for most people.
  • The High Dose: 10% or higher is for specific concerns like stubborn texture or oiliness.
  • The Rysun Standard: We implement up to 50 inspection procedures to ensure that whatever percentage is on the label is exactly what is in the bottle. We formulate our high-percentage serums with soothing agents to prevent the irritation sometimes caused by potent Niacinamide.

Conclusion

Knowing how to use niacinamide serum is simple: Cleanse, Apply, Layer, and Moisturize. It is a versatile, forgiving ingredient that fits into almost any routine.

However, the efficacy of the routine depends on the quality of the product. At Rysun Biotechnology, we combine over a decade of experience with Swiss-inspired precision to manufacture Niacinamide serums that are stable, effective, and a joy to use.

 

FAQs

Q1: Can I use Niacinamide serum every day?
A: Yes. It is gentle enough for twice-daily use (AM and PM). In fact, Rysun recommends consistent daily use to see real changes in pore size and oil production.

Q2: Should I apply Niacinamide to damp or dry skin?
A: Damp skin is generally better for absorption, but ensure it isn't dripping wet.

Q3: Can I use Niacinamide if I have sensitive skin?
A: Yes, it is actually an anti-inflammatory. However, if you experience redness, you might be using a concentration that is too high (10%+). Rysun creates 5% formulas specifically for sensitive skin markets.

Q4: Why does my Niacinamide serum "pill" (ball up) under makeup?
A: This is usually a sign of a cheap formulation using too much thickener. Rysun’s R&D team focuses on texture optimization to ensure our serums layer smoothly under foundation without pilling.

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