Niacinamide and Hyaluronic Acid Serum: Benefits, How to Use & Expert Guide

Learn why niacinamide and hyaluronic acid work perfectly together, how to use them in a routine, and formulation insights from Rysun Cosmetics—your trusted skincare manufacturer.

Niacinamide and Hyaluronic Acid Serum: Why This Duo Works and How to Use It

Introduction

In modern skincare formulations, niacinamide and hyaluronic acid are among the most effective, science-backed ingredients for improving skin health. Many users wonder whether these two can be used together and what benefits this combination offers.
As Rysun Biotechnology, a research-driven cosmetics manufacturer with a strong R&D foundation and over 105 product patterns and 253 intellectual properties, we frequently formulate serums that combine both ingredients for global brands. This article provides a professional and easy-to-understand guide on how niacinamide and hyaluronic acid work together in skincare.

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Can You Use Niacinamide and Hyaluronic Acid Together?

Yes — niacinamide and hyaluronic acid pair perfectly.
They complement each other’s functions and enhance product performance without causing irritation.

• Hyaluronic acid (HA) hydrates and plumps the skin.
• Niacinamide (Vitamin B3) strengthens the skin barrier, brightens, and regulates oil production.

When layered or combined in one serum, they create a balanced and effective routine suitable for all skin types.

At Rysun, our Research Institute often blends these two ingredients to create multi-benefit serums for hydration, brightening, and barrier repair.

Benefits of Combining Niacinamide and Hyaluronic Acid

1. Deep Hydration + Long-Lasting Moisture

Hyaluronic acid attracts water to the skin, while niacinamide increases ceramide production to lock moisture in.
This makes the duo ideal for dry or dehydrated skin.

2. Strengthens the Skin Barrier

Niacinamide enhances the skin’s natural barrier, and HA maintains moisture levels—together improving resilience against environmental stress.

3. Brightening and Glow-Enhancing Effects

Niacinamide reduces dullness and evens skin tone. When the skin is well-hydrated by HA, it naturally appears plumper and more radiant.

4. Reduces Oil and Minimizes Pores

Niacinamide helps regulate sebum production, making this combination suitable even for oily or acne-prone skin.

5. Gentle and Suitable for Sensitive Skin

Both ingredients are non-irritating and well-tolerated.
At Rysun, we often include Centella Asiatica, panthenol, or ceramides in such formulas for added soothing benefits.

How to Use Niacinamide and Hyaluronic Acid in a Skincare Routine

Method 1: Apply Hyaluronic Acid First, Then Niacinamide

• Cleanser

• HA serum (on damp skin)

• Niacinamide serum

• Moisturizer

• Sunscreen (AM)

Applying HA first boosts moisture absorption and prepares the skin for niacinamide.

Method 2: Use a Combined Niacinamide + Hyaluronic Acid Serum

Rysun develops custom formulations that incorporate both ingredients in a single serum. This provides:

• Lightweight texture
• Improved absorption
• Balanced hydration & brightening
• Reduced formulation complexity for brands

This option is ideal for brands seeking multifunctional product lines with high consumer demand.

Ideal Skin Types for This Duo

✔ Dry skin
✔ Oily or acne-prone skin
✔ Combination skin
✔ Dull or uneven skin tone
✔ Sensitive skin
✔ Mature skin

Because the combination is so versatile, over 700+ brands worldwide partner with Rysun to build serums featuring these two hero ingredients.

How Rysun Formulates With Niacinamide & Hyaluronic Acid

Our R&D team typically considers:

1. Concentration Levels

• Niacinamide 2–5% for daily serums
• Multi-molecular HA for layered hydration

2. pH Compatibility

Both ingredients perform well in a pH range around 5.0–7.0, making formulation stable and consumer-friendly.

3. Texture Requirements

Depending on market needs (Asian, European, African, Middle Eastern), we adjust:

• Viscosity
• Absorption rate
• Skin finish (dewy vs. matte)

4. Adding Supporting Ingredients

To enhance performance, Rysun serums often include:

• Panthenol
• Ceramides
• Beta-glucan
• Amino acids
• Centella Asiatica extract

These combinations boost hydration, soothing, and barrier repair.

Conclusion

Niacinamide and hyaluronic acid are a powerful skincare duo suitable for all skin types. When used together—whether layered or combined in a single serum—they deliver hydration, brightening, oil control, and improved resilience.
As a leading research-focused cosmetics manufacturer, Rysun Biotechnology specializes in developing customized niacinamide + HA serums backed by strict quality testing and advanced formulation technology.

Whether your brand needs private label, OEM, or ODM solutions, we deliver high-performance formulas tailored to your market.

FAQs

1. Can niacinamide and hyaluronic acid be used together every day?

Yes, they are gentle enough for daily or twice-daily routines.

2. Should I apply HA or niacinamide first?

Apply hyaluronic acid first, then niacinamide, or use a combined serum.

3. Is this combination good for oily skin?

Yes. Niacinamide helps control oil production, while HA provides lightweight hydration.

4. Can sensitive skin use these ingredients?

Absolutely. Both are mild and suitable for sensitive or irritated skin.

5. Can I use vitamin C with niacinamide and HA?

Yes. All three ingredients can be used in the same routine without issues.