Why Do Some Dermatologists Not Recommend Hyaluronic Acid? The Science Explained | Rysun Biotech

Friday, 12/5/2025

Curious why do some dermatologists not recommend hyaluronic acid? It often comes down to molecular weight and climate. Learn how Rysun Biotech’s R&D overcomes these risks with safe, stable formulations.

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The Controversy Explained: Why Do Some Dermatologists Not Recommend Hyaluronic Acid?

Introduction
Hyaluronic Acid (HA) has long been the darling of the skincare world. It is in serums, creams, and even makeup. Yet, a growing number of skincare professionals are raising a red flag. A search of the keyword "Why do some dermatologists not recommend hyaluronic acid" reveals concerns about inflammation, dryness, and over-marketing.

At Guangzhou Rysun Biotechnology, we welcome this scrutiny. Founded in 2014 by Ivy Wong specifically to address "inconsistent quality" in the market, our company thrives on scientific truth. Guided by early discussions with a Swiss anti-aging expert and supported by our Research Institute, we know that HA is not a magic wand—it is a chemical tool that must be used correctly.

Here, our team of 20 leading scientists breaks down the arguments against HA and explains how high-quality manufacturing solves them.

Here is our private label Hyaluronic Acid Serum, welcome to have a look.

 

Reason 1: The "Vampire Effect" (It Can Dry You Out)

The primary reason some dermatologists hesitate to recommend generic HA serums is environmental. HA is a humectant—it grabs water.

  • The Problem: If you apply HA in a dry climate (low humidity) and do not seal it in with an occlusive moisturizer, the HA molecule will search for water. If there is no water in the air, it draws water up from the deeper layers of your skin to the surface, where it evaporates. This leaves the skin more dehydrated than before.
  • The Rysun Solution: We agree with the dermatologists: HA alone is not enough. This is why Rysun emphasizes practical solutions. Our R&D team formulates HA serums that are pre-blended with barrier-locking ingredients (like Ceramides or Polyglutamic Acid). We don't just sell water; we sell hydration retention systems.

Reason 2: The Inflammation Risk (Molecular Weight Matters)

This is the most serious scientific concern.

  • The Problem: In an attempt to make HA penetrate deeper, some manufacturers chop the molecule into extremely small fragments (Ultra-Low Molecular Weight). Studies suggest that these tiny fragments can be interpreted by the skin as "damage signals," potentially triggering an inflammatory immune response. This is why some doctors warn that HA can be "pro-inflammatory."
  • The Rysun Solution: Precision biology. With 253 intellectual properties, Rysun has mastered the art of molecular balance. We avoid the "danger zone" of inflammatory molecular weights. Instead, we use a calculated multi-molecular weight complex that safely hydrates various layers of the epidermis without triggering the skin's alarm system.

Reason 3: It interferes with Essential Ingredients

Some dermatologists argue that consumers are replacing vital actives (like Retinol or Vitamin C) with Hyaluronic Acid, which is functionally just a moisturizer. They argue HA is "overhyped" at the expense of ingredients that actually repair skin.

  • The Rysun Solution: We view HA as a supporting actor, not always the lead. Leveraging our 105 product patterns, we create "hybrid serums" where HA is the delivery vehicle for more potent actives. We help brands create products where HA supports the barrier while Vitamin C or Peptides do the heavy lifting.
  •  

The Manufacturer’s Role: Why Quality is the Answer

When dermatologists criticize Hyaluronic Acid, they are usually criticizing poorly formulated, mass-market products. They are warning against cheap, sticky serums that sit on the skin or aggressive formulas that irritate it.

Rysun Biotechnology stands on the side of the dermatologists.

  • Strict QC: We implement up to 50 inspection procedures per product. We test for purity, pH balance, and stability.
  • Global Insight: Exporting to 50+ countries, we understand how different climates affect HA performance. We formulate differently for a brand in humid Southeast Asia versus a brand in dry Northern Europe.

Conclusion

So, why do some dermatologists not recommend hyaluronic acid? Usually, because they have seen the results of bad science.

However, when formulated correctly—with safe molecular weights and occlusive support—HA remains one of the best hydrators in nature. At Rysun Biotechnology, we combine deep industry expertise with Swiss-inspired standards to manufacture HA products that even the most skeptical dermatologists can trust.

 

FAQs

Q1: Is Hyaluronic Acid safe for sensitive skin?
A: Yes, if the molecular weight is correct. High molecular weight HA is very soothing. Irritation usually comes from preservatives or extremely low molecular weight versions. Rysun formulates specifically for sensitive skin safety.

Q2: What is a better alternative to Hyaluronic Acid?
A: Some dermatologists prefer Glycerin or Polyglutamic Acid. Rysun’s Research Institute works with all of these humectants and can help your brand decide which ingredient (or blend) fits your target market best.

Q3: Should I apply Hyaluronic Acid to dry or damp skin?
A: Always damp skin. Applying it to dry skin increases the risk of the "drying effect" mentioned above. As a manufacturer, Rysun advises brands to include these application instructions on their packaging.

Q4: Does Rysun test for inflammation risks?
A: Yes. Our multidisciplinary team includes biology and dermatology experts who oversee product testing to ensure our formulations are soothing and non-inflammatory before they ever reach the market.

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