When to Use Peptide Serum: Morning, Night & Routine Order | Rysun Biotech

Friday, 12/26/2025

Confused about when to use peptide serum? Unlike acids, peptides are flexible. Rysun Biotech’s R&D experts explain the best time, order, and age to start using these Swiss-inspired anti-aging builders.

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Timing the Repair: The Expert Guide on When to Use Peptide Serum

Introduction
In the complex world of skincare layering, ingredients like Retinol and Vitamin C come with strict schedules. But what about Peptides? As the demand for "gentle anti-aging" grows, consumers and brand owners are frequently asking: "When to use peptide serum?"

At Guangzhou Rysun Biotechnology, we view Peptides as the "diplomats" of the skincare world. Founded in 2014 by Ivy Wong to solve the industry's "inconsistent quality," and rooted in insights from a Swiss anti-aging expert, we know that Peptides are unique because they are biologically compatible with the skin’s natural functions.

Backed by our Research Institute and 20 leading scientists, here is the definitive guide on the timing, frequency, and order of application for Peptide serums.

Here is our private label face serum collection, pls click here for more details.

 

1. Time of Day: The 24-Hour Worker

The first rule of when to use peptide serum is that there are very few rules.

  • The Science: Unlike Retinol (which degrades in sunlight) or heavy acids (which increase sun sensitivity), Peptides are generally non-photosensitive. They are stable chains of amino acids that work around the clock.
  • The Rysun Verdict: We recommend using Peptide serum Twice Daily (AM and PM).
    • In the Morning: To arm the skin with barrier support against environmental stress.

    • At Night: To signal collagen repair while the body is in its regenerative sleep cycle.

2. Routine Order: The "Thinnest to Thickest" Rule

Knowing where to put it in the routine is just as important as when.

  • The Logic: Peptides act as messengers. They need to reach the deeper layers of the epidermis to "signal" the fibroblasts. If you apply them over an oil or thick cream, they cannot penetrate.
  • The Rysun Guide:
  1. Cleanser
  2. Toner
  3. Peptide Serum (Apply here!)
  4. Moisturizer / Oil
  5. SPF (AM)
  • R&D Insight: Rysun utilizes advanced delivery systems (part of our 253 intellectual properties) to ensure our Peptide serums have a lightweight molecular structure, allowing them to absorb instantly before you apply heavier layers.

3. The "Conflict" Check: When NOT to Use It

While Peptides are gentle, they are chemically fragile.

  • The Science: Peptides are prone to hydrolysis (breaking apart) if exposed to extremely low pH levels.
  • The Warning: Be careful when using Peptides at the exact same time as strong AHAs (Glycolic Acid) or L-Ascorbic Acid (Pure Vitamin C). The acidity can potentially render the peptides less effective.
  • The Rysun Solution: We formulate Practical Solutions. We often use "buffered" peptides or stable Vitamin C derivatives in our formulas so that brands don't have to worry about these conflicts. However, if layering separate products, we advise waiting 10 minutes between the acid and the peptide.

4. The Age Factor: When to Start?

"When to use peptide serum" also refers to the stage of life.

  • Mid-20s (Pre-juvenation): This is when natural collagen production begins to slow by 1% per year. Using Peptides now preserves the skin's "bounce."
  • 30s and 40s (Repair): Peptides become essential to signal the repair of fine lines and loss of elasticity.
  • The Rysun Standard: Leveraging our 105 product patterns, we manufacture different strengths—lightweight preventative blends for younger demographics, and concentrated Signal Peptide complexes for mature skin.

 

The Manufacturer’s Role: Stability is Everything

The reason some consumers struggle with "when" to use peptides is that low-quality serums are sticky or pill under makeup.

Rysun Biotechnology solves this through superior engineering:

  • Cosmetic Elegance: We ensure our Peptide serums are non-tacky and absorb fully, making them perfect for morning use under foundation.
  • Stability: Peptides are expensive. If they degrade in the bottle, the timing doesn't matter. Our 50 inspection procedures ensure that the amino acid chains remain intact and active from the first drop to the last.

Conclusion

So, when to use peptide serum?
Use it morning and night, on clean skin, starting in your mid-20s. It is the most versatile, low-risk anti-aging tool in your arsenal.

At Rysun Biotechnology, we combine over 10 years of global experience with Swiss-inspired precision to manufacture Peptide serums that are stable, effective, and easy to fit into any routine. Partner with us to bring the science of cellular communication to your customers.

 

FAQs

  • Q1: Can I use Peptide serum with Retinol?
    A: Yes! This is a powerful anti-aging combination. You can use them together at night. The Peptides help soothe the skin while the Retinol increases turnover. Rysun often manufactures "Power Duos" containing both.
  • Q2: Can I use Peptide serum around my eyes?
    A: Absolutely. In fact, specific peptides like Argireline (Botox-mimicking) are designed for crow's feet. Rysun manufactures specialized Peptide Eye Serums that are safe for this delicate area.
  • Q3: Do I need to wait after applying Peptide serum?
    A: No. Because Rysun formulates for fast absorption, you can apply your moisturizer immediately after the serum feels tacky or absorbed (usually 30 seconds).
  • Q4: Is it better to use Peptides in a serum or a cream?
    A: A serum is generally better because it contains a higher concentration of the active ingredient and penetrates deeper. A cream seals it in. Rysun recommends a Peptide Serum for the "treatment" step.
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