What Actually Causes Dark Spots? The Science of Melanogenesis | Rysun Biotech

Wednesday, 01/21/2026

Asking "What actually causes dark spots?" It isn't just the sun. From inflammation to hormones, Rysun Biotech’s R&D experts explain the biological triggers and how to formulate targeted solutions.

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What Actually Causes Dark Spots? A Scientific Guide to the Biological Roots of Pigmentation

Introduction
Hyperpigmentation is one of the top three skin concerns globally. Yet, despite buying countless brightening serums, many consumers feel their results are lackluster. This leads to the frustrated question: "What actually causes dark spots?"

At Guangzhou Rysun Biotechnology, we believe you cannot cure what you do not understand. Founded in 2014 by Ivy Wong to solve the market's "inconsistent quality," and inspired by deep discussions with a Swiss anti-aging expert, we approach skincare not as magic, but as biology.

Backed by our Research Institute and 20 leading scientists, we are here to pull back the curtain on Melanogenesis—the biological process that creates dark spots—and explain why understanding this mechanism is the key to manufacturing products that actually work.

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The Mechanism: Meet the Melanocyte

To answer "what actually causes dark spots," we must look deep into the epidermis.

  • The Factory: You have cells called Melanocytes. Think of these as pigment factories.
  • The Engine: Inside the factory is an enzyme called Tyrosinase.
  • The Process: When triggered, Tyrosinase converts amino acids into Melanin (pigment). This pigment is packaged into bundles and shipped up to the surface of your skin to protect the DNA from damage.

A "dark spot" is simply this protection mechanism gone into overdrive. But what pushes the "On" button?

Trigger 1: UV Radiation (The External Aggressor)

The sun is the #1 cause.

  • The Science: When UV rays hit the skin, they generate free radicals (oxidative stress). This signals the Melanocytes to produce melanin as a protective umbrella.
  • The Rysun Insight: This is why we emphasize antioxidants in our formulations. By neutralizing free radicals, we stop the signal before the pigment is even made.

Trigger 2: Inflammation (The Injury)

This is the cause of "acne marks" (Post-Inflammatory Hyperpigmentation or PIH).

  • The Science: When the skin is inflamed (due to acne, a cut, or harsh chemicals), the immune system triggers the Melanocytes to release pigment as a defense response.
  • The Rysun Insight: This is why aggressive scrubs often make dark spots worse. We advocate for Practical Solutions—gentle, barrier-repairing brighteners that soothe inflammation rather than irritating it.

Trigger 3: Hormones (The Internal Signal)

This causes Melasma.

  • The Science: Estrogen and Progesterone (during pregnancy or contraceptive use) can hypersensitize the Melanocytes. Even a tiny amount of sun exposure can trigger massive pigment production in specific patterns.
  • The Rysun Insight: Hormonal pigment sits deep in the skin. We use our 253 intellectual properties to develop advanced delivery systems that transport active ingredients deep enough to reach these overactive cells.

 

The Manufacturer’s Solution: Targeting the Cause, Not the Symptom

If you know what actually causes dark spots, you can manufacture a product that stops them. Many generic manufacturers just put an acid in a bottle and hope for the best.

Rysun Biotechnology engineers specific solutions for each trigger:

  • For UV Triggers: We formulate stable Vitamin C and Ferulic Acid serums to neutralize the oxidative stress.
  • For Enzyme Triggers: We use Kojic Acid and Alpha Arbutin to inhibit Tyrosinase (turning off the engine).
  • For Transfer Triggers: We use Niacinamide to block the pigment from reaching the surface cells.

Quality Control is Key:
Pigment inhibitors are chemically fragile. If they oxidize, they stop working. Our 50 inspection procedures ensure that every brightening serum leaving our Guangzhou facility is stable, potent, and biologically active.

Conclusion

So, what actually causes dark spots?
It is a chain reaction: Trigger (Sun/Injury) Enzyme Activation Pigment Production Surface Transfer.

 

To fade a spot, you must interrupt this chain. At Rysun Biotechnology, we combine over 10 years of manufacturing excellence with Swiss-inspired precision. We create formulations that target every stage of Melanogenesis. Partner with us to manufacture a brightening solution that is rooted in science, not guesswork.

 

FAQs

Q1: Does blue light from screens cause dark spots?
A: Yes. Recent research shows that High-Energy Visible (HEV) light from phones and computers can trigger Melanogenesis, especially in deeper skin tones. Rysun formulates "Digital Defense" serums with specific antioxidants to combat this.

Q2: Why do dark spots get darker before fading?
A: As your skin exfoliates, the pigment that was trapped deep in the skin moves to the surface to be shed. This can temporarily make the spot look darker or more defined before it flakes off.

Q3: Can heat cause dark spots?
A: Yes. Extreme heat (saunas, hot yoga) causes inflammation (vasodilation), which can trigger Melasma even without the sun. Rysun recommends cooling, soothing ingredients for Melasma-prone skin.

Q4: How does Rysun ensure their products target the root cause?
A: Our Research Institute tests ingredients against specific biological markers (like Tyrosinase activity). We verify that the formula actually inhibits the enzyme in a lab setting before we mass produce it.

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